Calcium-channel blocking agents may increase tacrolimus blood concentrations and therefore require dosage reduction of prograf see drug interactions .

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Tacrolimus can make you more likely to get infections or may worsen any current infectionsThereforewash your hands well to prevent the spread of infectionAvoid contact with people who have infections that may spread to otherssuch as chickenpoxmeaslesfluConsult your doctor if you have been exposed to an infection or for more details.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongationBefore using tacrolimustell your doctor or pharmacist of all the drugs you take and if you have any of the following conditionscertain heart problemsheart failureslow heartbeatQT prolongation in the EKGfamily history of certain heart problemsQT prolongation in the EKGsudden cardiac death

This medication may also increase your risk of getting a rare but very serioussometimes fatalbrain infectionprogressive multifocal leukoencephalopathy-PMLGet medical help right away if any of these rare but very serious side effects occurclumsinessloss of coordinationweaknesssudden change in your thinkingsuch as confusiondifficulty concentratingdifficulty moving your musclesproblems with speechseizurevision changes.

Some people taking Prograf after a kidney transplant have developed diabetesThis effect has been seen most commonly in people who are Hispanic or African-AmericanTalk with your doctor about your individual risk of diabetes if you have concerns.

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