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Deeb et al2013Disrupted Clhomeostasis contributes to reductions in the inhibitory efficacy of diazepam during hyperexcited statesEur J Neurosci 38 2453 PMID23627375.

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9Although many of the undesirable features of corticosteroid therapy can be minimized by ADTas in any therapeutic situationthe physician must carefully weigh the benefit-risk ratio for each patient in whom corticoid therapy is being considered.

How is this drug usedPrednisone is FDA approved for the treatment of leukemias and lymphomas in adults and acute leukemia of childhoodIt is also indicated for hypercalcemiahigh levels of calcium in the bloodassociated with cancer and mycosis fungoidesPrednisone may also be used to help prevent or reduce nausea and vomitingor to reduce the swelling surrounding cancerous tumors to relieve pressure caused by the swellingIt is important for patients to remember that physicians have the ability to prescribe medication for conditions other than those for which the drug has been approved by the FDAPatients who have received a prescription of this drug for a condition other than which it is approved may wish to discuss this issue with their physicianWhat is the mechanism of actionPrednisone belongs to a class of drugs called glucocorticoidsPrednisone produces its anti-cancer effects by inhibiting inflammatory agents in the bodywhich have been implicated in the development or growth of some cancers.

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7In using ADT it is importantas in all therapeutic situations to individualize and tailor the therapy to each patientComplete control of symptoms will not be possible in all patientsAn explanation of the benefits of ADT will help the patient to understand and tolerate the possible flare-up in symptoms which may occur in the latter part of the off-steroid dayOther symptomatic therapy may be added or increased at this time if needed.

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