A single-dose pharmacokinetic study demonstrated that the disposition of bupropion and its metabolites in elderly subjects was similar to that of younger subjects; however, another pharmacokinetic study, single and multiple dose, has suggested that the elderly are at increased risk for accumulation of bupropion and its metabolites see clinical pharmacology .
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additionally, in a study comparing 14-day dosing with wellbutrin xl tablets 300 mg once daily to the sustained-release formulation of bupropion at 150 mg 2 times daily, equivalence was demonstrated for peak plasma concentration and area under the curve for bupropion and the 3 metabolites.
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compared with a placebo control, bupropion approximately doubles smoking quit rates.
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bupropion is metabolised to its major active metabolite hydroxybupropion primarily by the cytochrome p450 cyp2b6 see section 5.
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according to the manufacturer of wellbutrin, drinking excessive amounts or abruptly withdrawing from alcohol after chronic use may increase the risk of seizure event in patients taking bupropion.
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