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AminoglutethimidebarbituratesegphenobarbitalcarbamazepinehydantoinsegphenytoinisoproterenolmoricizinerifampinStJohn’s wortor sulfinpyrazone because they may decrease Quibron-T’s effectiveness Allopurinolbeta-blockersegpropranololcimetidinedisulfiramenoxacinestrogenfebuxostatfluvoxamineinterferon alphamacrolide antibioticsegclarithromycinerythromycinmethotrexatemexiletineoral contraceptivesbirth control pillspentoxifyllinepropafenonequinolone antibioticsegciprofloxacintacrinethiabendazoleticlopidinetroleandomycinverapamilviloxazineor zileuton because they may increase the risk of Quibron-T’s side effects Ephedrine because the risk of side effectssuch as nauseanervousnessand trouble sleepingmay be increased Halothane because the risk of side effects such as irregular heartbeat may be increased Ketamine because the risk of seizures may be increased Adenosinebenzodiazepinesegdiazepamflurazepamlorazepammidazolamdipyridamole IVlithiumor nondepolarizing muscle relaxantsegpancuroniumbecause their effectiveness may be decreased by Quibron-T.

The dosage is based on your medical conditionresponse to treatmentageweightlab teststheophylline blood levelsand other medications you may be takingBe sure to tell your doctor and pharmacist about all the products you useincluding prescription drugsnonprescription drugsand herbal productsTo reduce your risk of side effectsyour doctor may direct you to start this medication at a low dose and gradually increase your doseFollow your doctor’s instructions carefully.

Do not flush medications down the toilet or pour them into a drain unless instructed to do soProperly discard this product when it is expired or no longer neededConsult your pharmacist or local waste disposal company for more details about how to safely discard your product.

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Take this medication regularly to get the most benefit from itTo help you remembertake it at the same time(seach dayKeep taking this medication even if you feel wellDo not increase your dosetake this drug more oftenor stop taking it without first consulting your doctor.

If you have any questions about Quibron-Tplease talk with your doctorpharmacistor other health care providerQuibron-T is to be used only by the patient for whom it is prescribedDo not share it with other peopleIf your symptoms do not improve or if they become worsecheck with your doctorCheck with your pharmacist about how to dispose of unused medicine.

Take this medication by mouth as directed by your doctorusually once or twice dailySince different manufacturers have different ways to take this medicationask your doctor or pharmacist about the best time(sto take your brand of theophylline and if you should take the drug with or without food.

Clearance represents the volume of blood completely cleared of theophylline by the liver in one minuteValues listed were generally determined at serum theophylline concentrations 3 months of ageIn contrastthe large fraction of the theophylline dose excreted in the urine as unchanged theophylline and caffeine in neonates requires careful attention to dose reduction and frequent monitoring of serum theophylline concentrations in neonates with reduced renal functionSee WARNINGS

This information is a summary onlyIt does not contain all information about Quibron-TIf you have questions about the medicine you are taking or would like more informationcheck with your doctorpharmacistor other health care provider.

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Take the extended-release capsule or tablet every morning at the same time each dayYou may take your second dose 10 to 12 hours after the morning dose and before the evening mealunless your doctor tells you otherwise.

The patientor parent/care givershould be instructed to seek medical advice whenever nauseavomitingpersistent headacheinsomnia or rapid heart beat occurs during treatment with theophyllineeven if another cause is suspectedThe patientor parent/care givershould be instructed to contact their clinician if they develop a new illnessespecially if accompanied by a persistent feverif they experience worsening of a chronic illnessif they start or stop smoking cigarettes or marijuanaor if another clinician adds a new medication or discontinues a previously prescribed medicationPatients should be instructed to inform all clinicians involved in their care that they are taking theophyllineespecially when a medication is being added or deleted from their treatmentPatients should be instructed to not alter the dosetiming of the doseor frequency of administration without first consulting their clinicianIf a dose is missedthe patient should be instructed to take the next dose at the usually scheduled time and to not attempt to make up for the missed dose.

In patients with chronic obstructive pulmonary diseaseCOPDclinical studies have shown that theophylline decreases dyspneaair trappingthe work of breathingand improves contractility of diaphragmatic muscles with little or no improvement in pulmonary function measurements.

Selected from data included with permission and copyrighted by First DatabankIncThis copyrighted material has been downloaded from a licensed data provider and is not for distributionexpect as may be authorized by the applicable terms of use.

Other manifestations of theophylline toxicity include increases in serum calciumcreatine kinasemyoglobin and leukocyte countdecreases in serum phosphate and magnesiumacute myocardial infarctionand urinary retention in men with obstructive uropathy.

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