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multiple dosing of topamax 150 mg day in healthy volunteers did not affect the pharmacokinetics of venlafaxine or o-desmethyl venlafaxine.
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in one study of actively drinking patients with alcohol dependence, topamax was more effective than a placebo in initiating abstinence.
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in the monotherapy epilepsy controlled trial, the proportion of patients who experienced one or more cognitive-related adverse events was 19 for topamax 50 mg day and 26 for 400 mg day.
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