A series of generic meds is based on dapoxetine and sildenafil, allowing the patient to deal with the issue safely and effectively.
Information about Dapoxetine.
Dapoxetine undergoes rapid absorption and elimination resulting in minimal accumulation and has dose-proportional pharmacokineticswhich are unaffected by multiple dosing and do not vary between ethnic groupsFigure 2Dresser et al2006bDresser et al2004Modi et al2006The pharmacokinetic profile of dapoxetine suggests that it is a good candidate for on-demand treatment of PE.
Sommer et al2005compared vardenafil 10 mg30 minutes pre-intercourseand sertraline 50 mg4 hours pre-intercoursein a prospectiverandomizedcross-over studyEjaculation was assessed with IELT using a stopwatch and graded on a scale of 0 to 80almost never8almost alwaysThe degree of improvement in ejaculation grade was 2.9 with vardenafil and 1.86 with sertralineand the increases in IELT were 5.23 in vardenafil-treated patients and 2.87 in sertraline-treated patientsThis study suggests that there is a potential for vardenafil in the treatment of PE.
The use of topical anesthetic ointments is probably the oldest treatment for delaying ejaculationbut only a few controlled studies gave been reportedIn one studythe results of lidocaine-prilocaine cream 10 minutes before intercourse were describedBerkovitch et al 1995Alsoan aerosol formulation of lidocaine-prilocaine is effective in prolonging IELT and in improving sexual satisfaction in men with PE and their partnersThe main drawback of topical anesthetics is their potential to cause a reduction in penile sensation and vaginal numbness in his partner.
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medline, web of science, pica, embase and the proceedings of major international and regional scientific meetings were searched for publications or abstracts published during the period 1993 2012 that used the word dapoxetine in the title, abstract or keywords.