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Immediately telephone your doctor or the Poisons Information Centretelephone 13 11 26 or New Zealand 0800 POISON or 0800 764766for adviceor go to Accident and Emergency at your nearest hospitalif you think that you or anyone else may have taken too much Roxithromycin SandozDo this even if there are no signs of discomfort or poisoningYou may need urgent medical attention.

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one of the aims of the review was to compare the clinical efficacy of once and twice daily regimens of roxithromycin, but the authors combine the results of the 2 regimes for some analyses, under the assumption that the 2 regimes give an equivalent response.

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Studies in rats have shown that amiloride is excreted in milk in concentrations higher than those found in bloodbut it is not known whether MIDAMORamilorideis excreted in human milkBecause many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from MIDAMORamiloridea decision should be made whether to discontinue nursing or to discontinue the drugtaking into account the importance of the drug to the mother.

Clinical studies ofMidamoramilorideModureticdid not include sufficient numbers of subjects aged 65 and over to determine whether they responded differently from younger subjectsOther reported clinical experience has not identified differences in responses between the elderly and younger patientsIn generaldose selection for an elderly patient should be cautioususually starting at the low end of the dosing rangereflecting the greater frequency of decreased hepaticrenal or cardiac functionand of concomitant disease or other drug therapy.

Amiloride is used to treat or prevent hypokalemialow potassium levels in the blood

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Take the extended-release capsule or tablet every morning at the same time each dayYou may take your second dose 10 to 12 hours after the morning dose and before the evening mealunless your doctor tells you otherwise.

The patientor parent/care givershould be instructed to seek medical advice whenever nauseavomitingpersistent headacheinsomnia or rapid heart beat occurs during treatment with theophyllineeven if another cause is suspectedThe patientor parent/care givershould be instructed to contact their clinician if they develop a new illnessespecially if accompanied by a persistent feverif they experience worsening of a chronic illnessif they start or stop smoking cigarettes or marijuanaor if another clinician adds a new medication or discontinues a previously prescribed medicationPatients should be instructed to inform all clinicians involved in their care that they are taking theophyllineespecially when a medication is being added or deleted from their treatmentPatients should be instructed to not alter the dosetiming of the doseor frequency of administration without first consulting their clinicianIf a dose is missedthe patient should be instructed to take the next dose at the usually scheduled time and to not attempt to make up for the missed dose.

In patients with chronic obstructive pulmonary diseaseCOPDclinical studies have shown that theophylline decreases dyspneaair trappingthe work of breathingand improves contractility of diaphragmatic muscles with little or no improvement in pulmonary function measurements.

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Other manifestations of theophylline toxicity include increases in serum calciumcreatine kinasemyoglobin and leukocyte countdecreases in serum phosphate and magnesiumacute myocardial infarctionand urinary retention in men with obstructive uropathy.

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