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Table 15 enumerates the incidencerounded to the nearest percentof treatment-emergent adverse reactions that occurred in 1or more of patients treated with intramuscular olanzapine for injectiondose range of 2.5-10 mg/injectionand with incidence greater than placebo who participated in the short-termplacebo-controlled trials in agitated patients with schizophrenia or bipolar I mania.

The following table provides injection volumes for delivering various doses of intramuscular olanzapine for injection reconstituted with Sterile Water for Injection.

Oral olanzapine should be administered in combination with fluoxetine once daily in the eveningwithout regard to mealsgenerally beginning with 5 mg of oral olanzapine and 20 mg of fluoxetineDosage adjustmentsif indicatedcan be made according to efficacy and tolerability within dose ranges of oral olanzapine 5 to 20 mg and fluoxetine 20 to 50 mgAntidepressant efficacy was demonstrated with olanzapine and fluoxetine in combination in adult patients with a dose range of olanzapine 6 to 18 mg and fluoxetine 25 to 50 mg.

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