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Improvement in symptoms may occur as soon as 2 weeksbut could take up to 12 weeks.

Because clinical trials are conducted under widely varying conditionsadverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice.

Dietary administration of cilostazol to male and female rats and mice for up to 104 weeksat doses up to 500 mg/kg/day in rats and 1000 mg/kg/day in micerevealed no evidence of carcinogenic potentialThe maximum doses administered in both rat and mouse studies wereon a systemic exposure basisless than the human exposure at the MRHD of the drugCilostazol tested negative in bacterial gene mutationbacterial DNA repairmammalian cell gene mutationand mouse in vivo bone marrow chromosomal aberration assaysIt washoweverassociated with a significant increase in chromosomal aberrations in the in vitro Chinese Hamster Ovary Cell assay.

Read the Patient Information Leaflet if available from your pharmacist before you start taking cilostazol and each time you get a refillIf you have any questionsask your doctor or pharmacist.

Improvement in symptoms may occur as soon as 2 weeksbut could take up to 12 weeks.

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It may also take a few weeks before you experience the full benefits of the drug.

It’s important to know that metoprolol could make you feel sleepyDon’t drive or operate machinery until you know how the drug affects you.

AMetoprolol is a medication that is used to treat anginahigh blood pressureor congestive heart failureMetoprolol is part of a group of medications called beta blockers that work to help blood vessels relax allowing for decrease in blood pressure and decreasing the workload of the heartThe prescribing information on metoprolol states that you should not stop taking metoprolol abruptlyStopping metoprolol may cause your condition that you are treating to become worse and cause serious problemsIn clinical studies of metoprololstopping the medication abruptly can increase a person’s chances for developing chest painheart attack or serious irregular heart rhythmsThis risk is greater in people with existing heart diseaseLori PoulinPharmD.

Although you can split the long-acting tabletsswallow the pills wholeDon’t crush or chew metoprolol.

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Tell your doctor if you have any type of previous injury to your liverYour doctor will likely check blood levels after a month of use if you fall into this category.

The table below summarizes other drug features of both tizanidine and cyclobenzaprine.

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