Thus, the specific changes in ethanol-maintained behavior by naltrexone were consistent with the neurochemical data.
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oral naltrexone is not a highly recommended therapy for the following reasons it has a very low retention rate concern about its safety in the setting of liver disease it blocks the analgesic effects of opioid agonists and should be discontinued 72 hours prior to elective surgery there is an elevated risk of fatal overdose upon discontinuation of oral naltrexone therapy 24 .
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the safety and efficacy of concomitant use of naltrexone hydrochloride and disulfiram is unknown, and the concomitant use of two potentially hepatotoxic medications is not ordinarily recommended unless the probable benefits outweigh the known risks.
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additionally, there is no data to show that naltrexone is stable in water or for how long.
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revia naltrexone is a member of the antidotes drug class and is commonly used for alcohol dependence and opiate dependence.
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